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Concomitant use of pectin and lovastatin, and other HMG-CoA reductase inhibitors may decrease absorption of the HMG-CoA reductase inhibitor. A 58-year-old man with hypertension, coronary artery disease, and hypercholesterolemia developed acute and generalized extremity weakness and chest pain while receiving diltiazem, lovastatin, nitrates, and enalapril. Similarly, lovastatin labeling recommends that therapy begin at 10 mg/day and not exceed 20 mg/day when prescribed with cyclosporine. These conditions may increase the amount of lovastatin in your blood. Using lovastatin may help prevent medical problems caused by such substances clogging the blood vessels.
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